Name: Chicken Alfredo Lasagna with Spinach Recipe
Prep time: 1 h
Cook time: 40 min
Total time: 1 h 40 min
Cuisine: Italian-American
Ingredients: 6 chicken tenders (or chicken breast); 1 tsp salt (or to taste); ½ tsp pepper; 1 tsp cayenne; 1 tsp garlic powder; 1 tsp Italian seasoning (or a mixture of oregano, parsley, and basil); 2 tbsp olive oil; 5 tbsp unsalted butter; ½ medium onion, finely chopped; 1 tbsp minced garlic; 1 tsp salt (or to taste); ½ tsp pepper; 1 tsp chili flakes; 1 tsp Italian seasoning; 5 tbsp all-purpose flour; 2 cups whole milk; 1 cup heavy cream (any kind of plain cream); 1 cup freshly grated Parmesan cheese; 2 cups chopped spinach; 14-15 lasagna sheets (approximately 1 pack); 3-4 cups shredded mozzarella cheese; Freshly chopped parsley for garnishing

If you love creamy, comforting pasta dishes, then you’re going to swoon over this Chicken Alfredo Lasagna with Spinach Recipe. It’s basically the best of both worlds—rich Alfredo sauce layered with tender chicken, fresh spinach, and lasagna noodles, all baked until bubbly and golden. I absolutely love how this turns out every single time, and I can’t wait for you to try it and feel the same!

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Why You’ll Love This Recipe

Creamy Flavor Explosion: The homemade Alfredo sauce is velvety smooth and packed with fresh Parmesan, making every bite heavenly.
Protein & Greens Combined: With juicy chicken and nutritious spinach layered right in, it’s a satisfying meal that feels balanced.
Family Favorite: My family always requests this on special occasions because it’s both comforting and elegant.
Easy to Customize: You can tweak the spice blend or add veggies so it works perfectly for your taste buds.

The image shows a glass baking dish filled with a lasagna that has several visible layers. The bottom layer is a red tomato sauce with some herbs, topped by a smooth creamy white cheese layer. Above that, there are pasta sheets with a beige color and wavy edges, followed by more tomato sauce and cheese layers. The top layer is golden brown melted cheese sprinkled with small green parsley pieces. The dish rests on a white marbled surface with a dark blue striped cloth in the background and a white pot with green plants nearby. Photo taken with an iphone --ar 2:3 --v 7 - Chicken Alfredo Lasagna with Spinach, creamy chicken lasagna, spinach lasagna casserole, baked Alfredo lasagna, cheesy chicken spinach pasta

Ingredients You’ll Need

To nail this Chicken Alfredo Lasagna with Spinach Recipe, you’ll want fresh, quality ingredients that build upon each other—think tender chicken, creamy sauce, and fresh spinach that brightens the dish right up. I always look for fresh Parmesan and good-quality lasagna sheets for the best results.

Flat lay of fresh raw chicken tenders, a neat pile of uncooked flat rectangular lasagna sheets, a small white bowl of bright green chopped spinach, a small white bowl filled with freshly grated pale yellow Parmesan cheese, a small white bowl containing shredded white mozzarella cheese, a few whole uncracked brown eggs, a small white bowl of golden olive oil, a small white bowl with peeled minced garlic, a small white bowl of finely chopped white onion, a small white bowl of creamy whole milk, a small white bowl of thick heavy cream, a few sprigs of fresh green parsley, fresh cracked black peppercorns scattered artistically, coarse sea salt crystals sprinkled tastefully, red chili flakes in a small white bowl placed neatly, a small white bowl holding pale yellow unsalted butter cubes, delicate dried Italian herb leaves arranged carefully, all ingredients arranged with perfect symmetry on a clean white marble surface, soft natural light, photo taken with an iPhone, professional food photography style, fresh ingredients, white ceramic bowls, no bottles, no duplicates, no utensils, no packaging --ar 2:3 --v 7 --p m7354615311229779997 - Chicken Alfredo Lasagna with Spinach, creamy chicken lasagna, spinach lasagna casserole, baked Alfredo lasagna, cheesy chicken spinach pasta

Chicken tenders: They cook quickly and stay juicy; you can swap for breast if you prefer leaner meat.
Olive oil: Helps the chicken get that golden sear without drying out.
Salt, pepper, cayenne, garlic powder, Italian seasoning: This blend seasons the chicken beautifully for bold flavor.
Unsalted butter: The base of the sauce — I like unsalted to control the seasoning better.
Onion and garlic: These build a tasty aromatic foundation for the Alfredo sauce.
All-purpose flour: Used to thicken the sauce just right.
Whole milk and heavy cream: The secret to that rich, creamy texture you crave.
Fresh Parmesan cheese: Grate your own if you can — it melts better and tastes fresher.
Spinach: Adds color, nutrition, and freshness, balancing out the richness.
Lasagna sheets: Boiled al dente so they hold up through baking without getting mushy.
Mozzarella cheese: For that gooey, melty layer everyone loves on top and between layers.
Fresh parsley: A bright garnish to finish the dish with a pop of freshness.

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Note: You’ll find the complete list of ingredients, along with their exact measurements, in the printable recipe card at the bottom of this post.

Variations

While this Chicken Alfredo Lasagna with Spinach Recipe is delicious as is, I love putting my spin on it now and then! Feel free to customize it to suit your pantry or cravings—you’ll find even small changes bring exciting new flavors and textures.

Add mushrooms: I once added sautéed cremini mushrooms between the layers for a deeper, earthier taste—my family was all in.
Switch up the greens: Try kale or Swiss chard instead of spinach if you want a different veggie flavor and texture.
Make it spicy: Crank up the cayenne pepper or toss in some red pepper flakes into the sauce if you like a bit of heat.
Go meatless: Simply skip the chicken and add extra spinach and mushrooms for a veggie-packed lasagna.

How to Make Chicken Alfredo Lasagna with Spinach Recipe

Step 1: Perfectly Season and Cook the Chicken

Start by coating your chicken tenders in salt, pepper, cayenne, garlic powder, and Italian seasoning, then rub in some olive oil. I always use a cast iron skillet heated on medium-high to get a nice sear—about 5 minutes per side usually does the trick. Don’t overcook; we want juicy, tender pieces that soak up all those delicious flavors when chopped. Once cooked, let the chicken rest for 5 minutes before chopping into bite-sized chunks. This resting step locks in those juices and keeps everything juicy—trust me, it makes a difference!

Step 2: Make the Creamy Spinach Alfredo Sauce

Next up, melt butter in a non-stick pan over medium-high heat. Toss in finely chopped onion and sauté until soft (around 3-5 minutes), then add minced garlic until fragrant—about 1-2 minutes. Stir in salt, pepper, chili flakes, and Italian seasoning, cooking for a minute more before whisking in all-purpose flour to create a roux. Toast it for a minute, then slowly pour in whole milk and heavy cream while stirring constantly. Lower the heat and let the sauce thicken—it should coat the back of a spoon but not be too stiff, since it’ll cook more in the oven. Turn off the heat, then fold in chopped spinach and freshly grated Parmesan cheese. Taste and adjust seasonings here—you’ll love how fresh and rich this sauce tastes!

Step 3: Assemble with Love

Preheat your oven to 375°F. Spread a few tablespoons of our luscious Alfredo sauce at the bottom of a 9×13″ baking dish to stop sticking. Lay down your first layer of 3 lasagna sheets, covering them with more sauce, a third of the chopped chicken, and about ¾ cup of shredded mozzarella. Repeat this process for the next two layers, using up the rest of the chicken. For the final layer, top with lasagna sheets, then spread the remaining sauce and finish with a generous cup of mozzarella cheese on top. This layering is what creates those irresistible pockets of creaminess and cheesy goodness everyone raves about.

Step 4: Bake to Perfection

A quick pro tip: stick 6-8 toothpicks into the lasagna in various spots before covering with foil—this acts like little tent poles, stopping the foil from sticking to that gorgeous cheesy top. Bake covered for about 40 minutes, then uncover and broil for 2-3 minutes to get a beautiful golden finish. After baking, let your masterpiece rest for 15 minutes so it sets and slices cleanly. Remove the toothpicks, sprinkle with fresh parsley, and you’re ready to slice and serve!

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Pro Tips for Making Chicken Alfredo Lasagna with Spinach Recipe

Don’t Skip Resting Your Chicken: Letting the chicken rest before chopping traps all those flavorful juices inside for tender bites.
Toast the Flour Properly: Give the flour a good minute over heat to avoid any raw flour taste in your Alfredo.
Use Toothpicks for Perfect Cheese Tops: This little trick stops foil from sticking, so your cheese layer stays gorgeous and intact.
Boil Pasta Al Dente: Slightly undercooked noodles stand up better to baking and prevent that mushy texture I used to hate.

How to Serve Chicken Alfredo Lasagna with Spinach Recipe

Chicken Alfredo Lasagna with Spinach Recipe - Serving

Garnishes

I love a simple sprinkle of freshly chopped parsley right after baking—it adds a fresh, bright note that cuts through all that creamy richness. Sometimes, I’ll also grate a little extra Parmesan on top for an indulgent final touch.

Side Dishes

Because this dish is so yummy and filling, I usually keep sides light. A crisp arugula salad with lemon vinaigrette or roasted asparagus pairs beautifully. Garlic bread is a classic option if you’re feeling indulgent and want to mop up every last bit of sauce.

Creative Ways to Present

Hosting a party? Try serving individual portions in small ramekins or oven-safe dishes. It’s much easier for guests to handle and looks super elegant. You can also sprinkle on some red pepper flakes or fresh basil leaves just before serving for a pop of color and flavor.

Make Ahead and Storage

Storing Leftovers

Whenever I have leftovers, I let the lasagna cool completely, then cover it tightly with plastic wrap and aluminum foil before popping it into the fridge. It keeps nicely for up to 4 days, and you’ll find flavors actually deepen after resting overnight.

Freezing

This Chicken Alfredo Lasagna with Spinach Recipe freezes really well. I wrap portions tightly in foil and then place them in freezer bags. When you’re ready, thaw overnight in the fridge for best results, and it will taste almost as fresh as the first day you made it.

Reheating

I usually reheat leftovers covered loosely with foil in a 350°F oven until warmed through, about 20 minutes. This keeps the top from drying out and maintains that creamy texture much better than microwaving.

FAQs

Can I use no-boil lasagna noodles for this recipe?

Yes, you can! If you use no-boil noodles, skip the boiling step but make sure you add a little extra sauce to keep the noodles moist as they cook. The baking time may need a few extra minutes to ensure noodles soften completely.
How do I prevent the sauce from getting too thick?

When cooking your Alfredo sauce, keep the heat low after adding milk and cream, stirring constantly. It thickens as it cools and bakes, so aim for a consistency that coats the spoon lightly—not too gloopy—so you get a perfectly saucy lasagna.
Can I make this recipe dairy-free?

It’s possible by substituting dairy ingredients with plant-based alternatives like vegan butter, unsweetened almond or oat milk, and dairy-free cheese options, though the flavor and creaminess will vary. I recommend testing a small batch first and adjusting seasonings accordingly.
What’s the best way to store leftovers?

Wrap leftovers tightly with plastic wrap and aluminum foil or place in airtight containers and refrigerate for up to 4 days. Make sure you cool the lasagna completely before storing to keep it fresh.

Final Thoughts

This Chicken Alfredo Lasagna with Spinach Recipe holds a special place in my heart because it marries those classic Italian flavors with a creamy twist that’s perfect for any occasion—whether an easy weeknight dinner or a family celebration. I hope you enjoy making and sharing it as much as I do; it’s one of those recipes that brings comfort and smiles with every bite. You’ve got this—give it a try, and let me know how it turns out!